Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3.
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| Abstract | :
Prior studies demonstrate that ethanol (EtOH) exposure induces the release of intracellular calcium (CA(2+) ) in modulation of γ-aminobutyric acid-ergic tone and produces concomitant alterations in sigma (σ)-1 protein expression that may contribute to the development EtOH dependence. However, the influence of CA(2+) released from endoplasmic reticulum (ER)-bound inositol triphosphate (IP3) and σ-1 receptors in regulating hippocampal function has yet to be delineated. |
| Year of Publication | :
2016
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| Journal | :
Alcoholism, clinical and experimental research
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| Volume | :
40
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| Issue | :
7
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| Number of Pages | :
1454-61
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| ISSN Number | :
0145-6008
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| URL | :
https://doi.org/10.1111/acer.13097
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| DOI | :
10.1111/acer.13097
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| Short Title | :
Alcohol Clin Exp Res
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