Probing local backbone geometries in intrinsically disordered proteins by cross-correlated NMR relaxation.
| Author | |
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| Abstract | :
An ultra-high-resolution NMR experiment for the measurement of intraresidue (1)H(i)-(15)N(i)-(13)C'(i) dipolar-chemical shift anisotropy relaxation interference is employed to extract information about local backbone geometries in intrinsically disordered proteins. The study of tumor suppressor BASP1 revealed a population shift of β-turn geometries at low pH conditions and a compaction of the BASP1 structural ensemble. |
| Year of Publication | :
2013
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| Journal | :
Angewandte Chemie (International ed. in English)
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| Volume | :
52
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| Issue | :
17
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| Number of Pages | :
4604-6
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| Date Published | :
2013
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| ISSN Number | :
1433-7851
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| URL | :
https://dx.doi.org/10.1002/anie.201210005
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| DOI | :
10.1002/anie.201210005
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| Short Title | :
Angew Chem Int Ed Engl
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